Authors: Dette, Holger
Kiss, Christine
Wong, Weng Kee
Title: Robustness of optimal designs for the Michaelis-Menten model under a variation of criteria
Language (ISO): en
Abstract: The Michaelis-Menten model has and continues to be one of the most widely used models in many diverse fields. In the biomedical sciences, the model continues to be ubiquitous in biochemistry, enzyme kinetics studies, nutrition science and in the pharmaceutical sciences. Despite its wide ranging applications across disciplines, design issues for this model are given short shrift. This paper focuses on design issues and provides a variety of optimal designs of this model. In addition, we evaluate robustness properties of the optimal designs under a variation in optimality criteria. To facilitate use of optimal design ideas in practice, we design a web site for generating and comparing different types of tailor-made optimal designs and user-supplied designs for the Michaelis-Menten and related models.
Subject Headings: C-optimal designs
Elfving's method
Extrapolation optimal design
Geometric design
Uniform design
Issue Date: 2009-01-13T08:00:41Z
Appears in Collections:Sonderforschungsbereich (SFB) 475

Files in This Item:
File Description SizeFormat 
TR_23-dette.pdfDNB198.78 kBAdobe PDFView/Open

This item is protected by original copyright

Items in Eldorado are protected by copyright, with all rights reserved, unless otherwise indicated.