Authors: Prachayasittikul, Supaluk
Prachayasittikul, Virapong
Ruchirawat, Somsak
Treeratanapiboon, Lertyot
Title: Novel activities of 1-adamantylthiopyridines as antibacterials, antimalarials and anticancers
Language (ISO): en
Abstract: To discover new bioactive lead compounds for medicinal purposes, herein, 2(1-adamantylthio)pyridine and derivatives (1-10) were prepared and tested for antibacterial (agar dilution method against 27 strains of microorganisms), antimalarial (against Plasmodium falciparum) and anticancer (MOLT-3, HepG2, HuCCA-1 and A549) activities. Results showed that all the tested derivatives selectively exerted antigrowth activity against Streptococci at 15-30 µg/mL. 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising antibacterial which selectively displays antigrowth activity against Vibrio cholerae, Vibrio parahaemolyticus, Edwardsiella tarda and beta-hemolytic Streptococcus group A with minimum inhibitory concentration of 30 µg/mL. The findings reveal that these 1-adamantylthiopyridines represent a novel class of antibacterial, antimalarial and anticancer agents with potential medicinal values.
Subject Headings: 1-adamantylthiopyridines
anticancer activities
Issue Date: 2009-07-08T07:20:08Z
Appears in Collections:Original Articles

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