Authors: Benda, Norbert
Bretz, Frank
Dette, Holger
Kiss, Christine
Title: Optimal designs for dose finding studies with an active control
Language (ISO): en
Abstract: Dose finding studies often compare several doses of a new compound with a marketed standard treatment as an active control. In the past, however, research has focused mostly on experimental designs for placebo-controlled dose finding studies. To the best of our knowledge, optimal designs for dose finding studies with an active control have not been considered so far. As the statistical analysis for an active controlled dose finding study can be formulated in terms of a mixture of two regression models, the related design problem is different to what has been investigated before in the literature. We present a rigorous approach to the problem of determining optimal designs for estimating the smallest dose achieving the same treatment effect as the active control. We determine explicitly the locally optimal designs for a broad class of models employed in such studies. We also discuss robust design strategies and determine related Bayesian and standardized minimax optimal designs. We illustrate the results by investigating alternative designs for a clinical trial which has recently appeared in a consulting project of one of the authors.
Subject Headings: minimax design
active control
dose estimation
dose response
Bayesian optimal designs
Issue Date: 2011-09-28
Appears in Collections:Sonderforschungsbereich (SFB) 823

Files in This Item:
File Description SizeFormat 
DP_3711_SFB823_Dette_Kiss_Benda_Bretz.pdfDNB1.25 MBAdobe PDFView/Open

This item is protected by original copyright

Items in Eldorado are protected by copyright, with all rights reserved, unless otherwise indicated.