Authors: Doungsoongnuen, Sutanun
Pingaew, Ratchanok
Prachayasittikul, Supaluk
Prachayasittikul, Virapong
Ruchirawat, Somsak
Suksrichavalit, Thummaruk
Worachartcheewan, Apilak
Title: Investigation on biological activities of anthranilic acid sulfonamide analogs
Language (ISO): en
Abstract: In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50 % inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.
Subject Headings: anthranilic acid
Issue Date: 2011-12-02
Appears in Collections:Original Articles

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