Authors: Budin, Siti Balkis
Idris, Muhd Hanis Md
Mohamed, Jamaludin
Osman, Mohamad
Title: Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats
Language (ISO): en
Abstract: Diabetes mellitus contributes to male sexual dysfunction and infertility by modulating oxidative damage. To date, a number of studies have demonstrated antioxidant properties of Hibiscus sabdariffa Linn. This study was designed to investigate the effects of H. sabdariffa UKMR-2 variety on sperm functioning of streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were allotted into four groups, namely control group (C), H. sabdariffa extract (HSE) group, diabetes group (D) and diabetes plus HSE group (D+HSE). HSE (100 mg/kg/body weight) was administered orally for 28 consecutive days. After 28-days of supplementation, the rats were sacrificed to obtain epididymal sperm. Administration of HSE significantly lowered the level of fasting blood glucose and increased plasma insulin level in D+HSE group as compared to D group (p<0.05). Sperm quality in the D+HSE group was improved with significantly higher sperm concentrations (p<0.05) and sperm motility (p<0.001) as well as lower percentage of sperm abnormality (p<0.05) as compared to the diabetic group. Plasma follicle-stimulating hormone (FSH) level was significantly elevated (p<0.05) in D+HSE group than in D group while no significant alteration in plasma testosterone and luteinizing hormone (LH) level were seen between groups. In conclusion, this study suggested that H. sabdariffa UKMR-2 variety has a potential protective role against diabetes-induced sperm damage.
Subject Headings: diabetes
Hibiscus sabdariffa UKMR-2
oxidative stress
sperm damage
URI: http://hdl.handle.net/2003/29784
http://dx.doi.org/10.17877/DE290R-5145
Issue Date: 2012-11-16
Appears in Collections:Original Articles

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