Autor(en): | Qureshi, Sameera Fatima Ali, Altaf Venkateshwari, Ananthapur Rao, Hygriv Jayakrishnan, M. P. Narasimhan, Calambur Shenthar, Jayaprakash Thangaraj, Kumarasamy Nallari, Pratibha |
Titel: | Atrial natriuretic peptide gene - a potential biomarker for Long QT syndrome |
Sprache (ISO): | en |
Zusammenfassung: | This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA- C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population. |
Schlagwörter: | atrial natriuretic peptide Long QT syndrome cardiogenesis biomarker polymorphisms |
URI: | http://hdl.handle.net/2003/33699 http://dx.doi.org/10.17877/DE290R-6728 |
Erscheinungsdatum: | 2014-08-15 |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Nallari_15082014_proof.pdf | DNB | 177.21 kB | Adobe PDF | Öffnen/Anzeigen |
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