Authors: Wang, Jing
Dai, Shu
Guo, Yan
Xie, Wen
Zhai, Yonggong
Title: Biology of PXR
Other Titles: Role in drug-hormone interactions
Language (ISO): en
Abstract: Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug metabolizing enzymes (DMEs) and transporters. Pregnane X receptor (PXR, NR1I2) functions as a master xenobiotic receptor involved in drug metabolism and drug-drug interactions by its coordinated transcriptional regulation of phase I and phase II DMEs and transporters. Recently, increasing evidences indicate that PXR can also mediate the endocrine disrupt or function and thus impact the integrity of the endocrine system. This review focuses primarily on the recent advances in our understanding of the function of PXR in glucocorticoid, mineralocorticoid, androgen and estrogen homeostasis. The elucidation of PXR-mediated drug-hormone interactions might have important therapeutic implications in dealing with hormone-dependent diseases and safety assessment of drugs.
Subject Headings: PXR
hormone homeostasis
xenobiotic receptor
drug-hormone interactions
Issue Date: 2014-07-07
Appears in Collections:Review Articles

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