Autor(en): | Chaudhary, Abha Sood, Swati Das, Pralay Kaur, Pushpinder Mahajan, Isha Gulati, Arvind Singh, Bikram |
Titel: | Synthesis of novel antimicrobial aryl himachalene derivatives from naturally occurring himachalenes |
Sprache (ISO): | en |
Zusammenfassung: | Five new 2,9,9-trimethyl-6,7,8,9-tetrahydro-benzocyclohepten-5-ylidene-amine derivatives (16a-16e) were synthesized from α-dehydro-ar-himachalene (11) that was originally prepared from an isomeric mixture of α, β and γ himachalenes (10), the abundant sesquiterpenes of Cedrus deodara essential oil. In addition, different aryl himachalenes derivatives (9, 12, 14 and 15) were also formed from 11. The structures of the synthesized compounds were confirmed on the basis of their NMR, IR and mass spectral data. The prepared compounds were tested against a group of sixteen organisms including gram positive and gram negative bacterial and fungal strains. The introduction of a series of substituted imine groups into aryl himachalenes at 5th position (16a-16e) enhanced antimicrobial activity as compared to the aromatized derivatives (9, 12, 14 and 15) against gram-positive bacteria Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus, and mycotoxigenic fungi Aspergillus parasiticus, A. ochraceous and A. sydowii. |
Schlagwörter: | himachalenes Cedrus deodara essential oil antimicrobial activity |
URI: | http://hdl.handle.net/2003/34004 http://dx.doi.org/10.17877/DE290R-7417 |
Erscheinungsdatum: | 2014-11-18 |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Singh_Das_18112014_proof.pdf | DNB | 280.11 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource ist urheberrechtlich geschützt. |
Diese Ressource ist urheberrechtlich geschützt. rightsstatements.org