Authors: Tila, Dena
Yazdani - Arazi, Seyede Narjes
Ghanbarzadeh, Saeed
Arami, Sanam
Pourmoazzen, Zhaleh
Title: PH-sensitive, polymer modified, plasma stable niosomes: promising carriers for anti-cancer drugs
Language (ISO): en
Abstract: The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymer introduced simultaneously pH-sensitivity and plasma stability properties in prepared niosomes. The pH-sensitivity and cytotoxicity of Mitoxantrone niosomes were evaluated in vitro in phosphate buffer with different pHs as well as using human ovarian cancer cell line (OVCAR-3), human breast cancer cell line (MCF-7) and human umbilical vein endothelial cells (HUVEC). Results showed that both cholesterol derivatives bearing formulations had pH-sensitive property and were found to release their contents under mild acidic conditions rapidly. In addition, the PEG-PMMI-CholC6-based niosomes could reserve the pH-sensitivity after incubation in plasma. Both Mitoxantrone-loaded pH-sensitive niosomes showed higher cytotoxicity than the conventional niosomes on OVCAR-3 and MCF-7 cell lines. However, both pH-sensitive niosomes exhibited lower cytotoxic effect on HUVEC cell line. Plasma stable, pH-sensitive niosomes could improve the cytotoxic effect and reduce the side effects of anti-tumor drugs.
Subject Headings: pH-sensitive plasma stable niosome
cytotoxic effect
Mitoxantrone
URI: http://hdl.handle.net/2003/34011
http://dx.doi.org/10.17877/DE290R-7465
Issue Date: 2015-01-06
Appears in Collections:Original Articles

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