Autor(en): Kobayashi, Yoshiro
Titel: Neutrophil biology
Sonstige Titel: an update
Sprache (ISO): en
Zusammenfassung: Neutrophil extracellular traps (NETs) are involved in bacterial killing as well as autoimmunity, because NETs contain proteases, bactericidal peptides, DNA and ribonucleoprotein. NETs are formed via a novel type of cell death called NETosis. NETosis is distinct from apoptosis, but it resembles necrosis in that both membranes are not intact so that they allow intracellular proteins to leak outside of the cells. Removal of NETs and neutrophils undergoing NETosis by phagocytes and its subsequent response are not completely clarified, as compared with the response after removal of either apoptotic or necrotic neutrophils by phagocytes. How neutrophil density in peripheral blood is kept within a certain range is important for health and disease. Although the studies on severe congenital neutropenia and benign ethnic neutropenia have provided unbiased views on it, the studies are rather limited to human neutropenia, and mice with a mutation of mouse counterpart gene often fail to exhibit neutropenia. Degranulation plays a critical role in bactericidal action. The recent studies revealed that it is also involved in immunomodulation, pain control and estrous cycle control. N1 and N2 are representative of neutrophil subpopulations. The dichotomy holds true in patients or mice with severe trauma or cancer, providing the basis of differential roles of neutrophils in diseases.
Schlagwörter: neutrophil extracellular traps
neutropenia
degranulation
neutrophil subpopulations
URI: http://hdl.handle.net/2003/34056
http://dx.doi.org/10.17877/DE290R-7799
Erscheinungsdatum: 2015-02-10
Enthalten in den Sammlungen:Review Articles

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
Kobayashi_10022015_proof.pdfDNB133.5 kBAdobe PDFÖffnen/Anzeigen


Diese Ressource ist urheberrechtlich geschützt.



Diese Ressource ist urheberrechtlich geschützt. rightsstatements.org