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dc.contributor.authorKangarlu-Haghighi, Katayoon-
dc.contributor.authorOryan, Shahrbanoo-
dc.contributor.authorNasehi, Mohammad-
dc.contributor.authorZarrindast, Mohammad-Reza-
dc.date.accessioned2016-05-23T08:54:56Z-
dc.date.available2016-05-23T08:54:56Z-
dc.date.issued2015-05-11-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/35003-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17051-
dc.description.abstractThe roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-peritoneal injection of ACPA induced anxiolytic-like effect (at dose of 0.05 mg/kg) and aversive memory deficit (at doses of 0.025 and 0.05 mg/kg). The results revealed that Pre-test intra-BLA infusion of muscimol (GABAA receptor agonist; at doses of 0.1 and 0.2 µg/mouse) or bicuculline (GABAA receptor antagonist; at all doses) impaired and did not alter aversive memory, respectively. All previous GABA agents did not have any effects on anxiety-like behaviors. Interestingly, pretreatment with a sub-threshold dose of muscimol (0.025 µg/mouse) and bicuculline (0.025 µg/mouse) did not alter anxiolytic-like behaviors induced by ACPA, while both drugs restored ACPA-induced amnesia. Moreover, muscimol or bicuculline increased and decreased ACPA-induced locomotor activity, respectively. Finally the data may indicate that BLA GABAA receptors have critical and different roles in anxiolytic-like effect, aversive memory deficit and locomotor activity induced by ACPA.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 14, 2015en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectACPAen
dc.subjectGABAen
dc.subjectanxietyen
dc.subjectmemoryen
dc.subjectamygdalaen
dc.subject.ddc610-
dc.titleThe effect of BLA GABAA receptors in anxiolytic-like effect and aversive memory deficit induced by ACPAen
dc.typeText-
dc.identifier.doi10.17179/excli2015-201-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
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