Authors: | Kangarlu-Haghighi, Katayoon Oryan, Shahrbanoo Nasehi, Mohammad Zarrindast, Mohammad-Reza |
Title: | The effect of BLA GABAA receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA |
Language (ISO): | en |
Abstract: | The roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-peritoneal injection of ACPA induced anxiolytic-like effect (at dose of 0.05 mg/kg) and aversive memory deficit (at doses of 0.025 and 0.05 mg/kg). The results revealed that Pre-test intra-BLA infusion of muscimol (GABAA receptor agonist; at doses of 0.1 and 0.2 µg/mouse) or bicuculline (GABAA receptor antagonist; at all doses) impaired and did not alter aversive memory, respectively. All previous GABA agents did not have any effects on anxiety-like behaviors. Interestingly, pretreatment with a sub-threshold dose of muscimol (0.025 µg/mouse) and bicuculline (0.025 µg/mouse) did not alter anxiolytic-like behaviors induced by ACPA, while both drugs restored ACPA-induced amnesia. Moreover, muscimol or bicuculline increased and decreased ACPA-induced locomotor activity, respectively. Finally the data may indicate that BLA GABAA receptors have critical and different roles in anxiolytic-like effect, aversive memory deficit and locomotor activity induced by ACPA. |
Subject Headings: | ACPA GABA anxiety memory amygdala |
URI: | http://hdl.handle.net/2003/35003 http://dx.doi.org/10.17877/DE290R-17051 |
Issue Date: | 2015-05-11 |
Rights link: | http://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | Original Articles |
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File | Description | Size | Format | |
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Zarrindast_11052015_proof.pdf | DNB | 643.78 kB | Adobe PDF | View/Open |
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