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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Ko, Eun-Yi | - |
dc.contributor.author | Lee, Seung-Hong | - |
dc.contributor.author | Ko, Ji-Yeon | - |
dc.contributor.author | Moon, Jeong Yong | - |
dc.contributor.author | Yoon, Weon-Jong | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.contributor.author | Roh, Seong Woon | - |
dc.contributor.author | Cho, Kichul | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.contributor.author | Kim, Daekyung | - |
dc.contributor.author | Kim, Kil-Nam | - |
dc.date.accessioned | 2016-06-03T16:18:41Z | - |
dc.date.available | 2016-06-03T16:18:41Z | - |
dc.date.issued | 2015-08-03 | - |
dc.identifier.issn | 1611-2156 | - |
dc.identifier.uri | http://hdl.handle.net/2003/35025 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-17073 | - |
dc.description.abstract | The anticancer effects of trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP), a chalcone derivative, were investigated in human leukemia HL-60 cells. Treatment of HL-60 cells with various concentration of DPEP resulted in a sequence of events characteristic of apoptosis, including loss of cell viability, morphological changes, and increased sub-G1 DNA content. We demonstrated that DPEP elevates reactive oxygen species (ROS) levels in HL-60 cells, and that the ROS scavenger N-acetylcysteine (NAC) could block DPEP-induced ROS generation and apoptosis. Western blot analysis revealed that DPEP inhibits Bcl-xL expression, leading to caspase-3 activation and poly-ADP-ribose polymerase (PARP) cleavage, thereby inducing apoptosis. However, NAC pretreatment significantly inhibited the activation of caspase-3 and PARP cleavage and reduced Bcl-xL levels. These findings provide the first evidence that DPEP may inhibit the growth of HL-60 cells and induce apoptosis through a ROS-mediated Bcl-xL pathway. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal;Vol. 14, 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | anticancer | en |
dc.subject | trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP) | en |
dc.subject | apoptosis | en |
dc.subject | reactive oxygen species (ROS) | en |
dc.subject | Bcl-xL | en |
dc.subject.ddc | 610 | - |
dc.title | Trans-1,3-diphenyl-2,3-epoxypropan-1-one, a chalcone derivative, induces apoptosis via ROS-mediated down-regulation of Bcl-xL in human leukemia HL-60 cells | en |
dc.type | Text | - |
dc.identifier.doi | 10.17179/excli2015-373 | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Enthalten in den Sammlungen: | Original Articles |
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Ko_Kim_03082015_proof.pdf | DNB | 850.64 kB | Adobe PDF | Öffnen/Anzeigen |
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