Autor(en): | Merzoug, Sameha Toumi, Mohamed Lamine |
Titel: | Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats |
Sprache (ISO): | en |
Zusammenfassung: | This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formal- dehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant rats were weighed throughout gestation and tested in two behavioral paradigms (elevated plus-maze and open field) at gestational days (GD) 1, 10 and 19 to evaluate the anxiety-like behavior and locomotive alterations. Another subset of rats was decapitated at GD19 to determine the hematological profile along with cortisol, 17β-estradiol, and progesterone plasma levels. Reproductive and fetal measures and observations were also performed to check for developmental deformities. Significant body weight loss, hemato-immune decline, hormonal changes, anxiety and lethargy signs, locomotor disabilities, repro- ductive failure and fetal weight decrease were observed in FA-exposed rats. Treatment with HP alleviated the reproductive and fetal weight defects. Its behavioral benefits were only seen at GD1 and 10. This flavanone ame- liorated some hematological parameters, decreased cortisol levels and increased 17β-estradiol rates. A potential preventive impact of HP was found against FA toxicity in pregnant rats. |
Schlagwörter: | formaldehyde hesperidin pathophysiology behavior gestation fetal development |
URI: | http://hdl.handle.net/2003/36126 http://dx.doi.org/10.17877/DE290R-18142 |
Erscheinungsdatum: | 2017-03-30 |
Rechte (Link): | http://creativecommons.org/licenses/by/4.0/ |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Merzoug_30032017_proof.pdf | DNB | 315.96 kB | Adobe PDF | Öffnen/Anzeigen |
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