Authors: Rajamanikyam, Maheshwari
Vadlapudi, Varahalarao
Parvathaneni, Sai Prathima
Koude, Dhevendar
Sripadi, Prabhakar
Misra, Sunil
Amanchy, Ramars
Upadhyayula, Suryanarayana Murty
Title: Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest
Language (ISO): en
Abstract: Bacteria belonging to the family Brevibacterieae are ubiquitous Gram positive organisms that are responsible for the feet odour and cheese aroma. Brevibacterium mcbrellneri is a relatively new member belonging to Brevibac- terieae. In the current manuscript we discuss isolation of biologically active metabolites from Brevibacterium mcbrellneri. Two aromatic esters were isolated from Brevibacterium mcbrellneri by “Bioassay guided fractiona- tion strategy” and identified as di-(2-ethylhexyl) phthalate and dibutyl phthalate by chemical characterization using biophysical techniques. The phthalate compounds show broad spectrum antibacterial activity and mosquito larvi-cidal activity. Mosquito larvicidal activity has been attributed to inhibition of acetylcholinesterase enzyme activity. These compounds were found to be cytotoxic in multiple cell lines causing cell cycle arrest in G1 phase.
Subject Headings: Brevibacterium mcbrellneri
di-(2-ethylhexyl) phthalate
dibutyl phthalate
Mosquito larvicidal
cell cycle arrest
Issue Date: 2017-03-24
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