Autor(en): | Rajamanikyam, Maheshwari Vadlapudi, Varahalarao Parvathaneni, Sai Prathima Koude, Dhevendar Sripadi, Prabhakar Misra, Sunil Amanchy, Ramars Upadhyayula, Suryanarayana Murty |
Titel: | Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest |
Sprache (ISO): | en |
Zusammenfassung: | Bacteria belonging to the family Brevibacterieae are ubiquitous Gram positive organisms that are responsible for the feet odour and cheese aroma. Brevibacterium mcbrellneri is a relatively new member belonging to Brevibac- terieae. In the current manuscript we discuss isolation of biologically active metabolites from Brevibacterium mcbrellneri. Two aromatic esters were isolated from Brevibacterium mcbrellneri by “Bioassay guided fractiona- tion strategy” and identified as di-(2-ethylhexyl) phthalate and dibutyl phthalate by chemical characterization using biophysical techniques. The phthalate compounds show broad spectrum antibacterial activity and mosquito larvi-cidal activity. Mosquito larvicidal activity has been attributed to inhibition of acetylcholinesterase enzyme activity. These compounds were found to be cytotoxic in multiple cell lines causing cell cycle arrest in G1 phase. |
Schlagwörter: | Brevibacterium mcbrellneri di-(2-ethylhexyl) phthalate dibutyl phthalate anti-bacterial Mosquito larvicidal cytotoxicity cell cycle arrest |
URI: | http://hdl.handle.net/2003/36127 http://dx.doi.org/10.17877/DE290R-18143 |
Erscheinungsdatum: | 2017-03-24 |
Rechte (Link): | http://creativecommons.org/licenses/by/4.0/ |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Upadhyayula_24032017_proof.pdf | DNB | 1.18 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource ist urheberrechtlich geschützt. |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons