Authors: Barros, Luiz Marivando
Duarte, Antonia Eliene
Waczuk, Emily Pansera
Roversi, Katiane
da Cunha, Francisco Assis Bezerra
Rolon, Mirian
Coronel, Cathia
Gomez, Maria Celeste Vega
de Menezes, Irwin Rose Alencar
da Costa, José Galberto Martins
Boligon, Aline Augusti
Hassan, Waseem
Souza, Diogo Onofre
da Rocha, João Batista Teixeira
Kamdem, Jean Paul
Title: Safety assessment and antioxidant activity of Lantana montevidensis leaves
Other Titles: contribution to its phytochemical and pharmacological activity
Language (ISO): en
Abstract: Lantana camara, the widely studied species, and L. montevidensis, the less studied species of the genus Lantana are both used in traditional medicine for the same purpose (anti-asthma, anti-ulcer, anti-tumor, etc). However, little is known about the toxicity of L. montevidensis and there is limited information on its chemical constituents. Here, we investigated for the first time the genotoxicity and cytotoxicity of the ethanolic (EtOH) and aqueous extracts from the leaves of Lantana montevidensis in human leukocytes, as well as their ossible interaction with human erythrocyte membranes in vitro. The antioxidant activities of both extracts were also investigated in chemical and biological models. Treatment of leukocytes with EtOH or aqueous extracts (1-480 µg/mL) did not affect DNA damage index, but promoted cytotoxicity at higher concentrations (240-480 µg/mL). Both extracts did not modify the osmotic fragility of human erythrocytes. The extracts scavenged DPPH radical and prevented Fe2+-induced lipid peroxidation in rat’s brain and liver homogenates, and this was likely not attributed to Fe (II) chelation. The HPLC analysis of the extracts showed different amounts of polyphenolic compounds (isoquercitrin, gallic acid, catechin, ellagic acid, apigenin, kaempferol, caffeic acid, rutin, quercitrin, quercetin, chlorogenic acid, luteolin) that may have contributed to these effects. These results supported information on the functional use of L. mon-tevidensis in folk medicine.
Subject Headings: Lantana montevidensis
osmotic fragility
Issue Date: 2017-04-21
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