Authors: Kohnen-Johannsen, Kathrin Laura
Kayser, Oliver
Title: Tropane alkaloids: chemistry, pharmacology, biosynthesis and production
Language (ISO): en
Abstract: Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are characterized by their unique bicyclic tropane ring system, can be divided into three major groups: hyoscyamine and scopolamine, cocaine and calystegines. Although all TAs have the same basic structure, they differ immensely in their biological, chemical and pharmacological properties. Scopolamine, also known as hyoscine, has the largest legitimate market as a pharmacological agent due to its treatment of nausea, vomiting, motion sickness, as well as smooth muscle spasms while cocaine is the 2nd most frequently consumed illicit drug globally. This review provides a comprehensive overview of TAs, highlighting their structural diversity, use in pharmaceutical therapy from both historical and modern perspectives, natural biosynthesis in planta and emerging production possibilities using tissue culture and microbial biosynthesis of these compounds.
Subject Headings: Tropane alkaloids
Scopolamine
Cocaine
Calystegine
Chemistry
Pharmacology
Biosynthesis
Biotechnological production
Subject Headings (RSWK): Alkaloide
Pharmazie
Biosynthese
URI: http://hdl.handle.net/2003/38035
http://dx.doi.org/10.17877/DE290R-20018
Issue Date: 2019-02-22
Rights link: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:Lehrstuhl Technische Biochemie

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