Authors: Souza Basso, Bruno de
Mesquita, Fernanda Cristina de
Bregolin Dias, Henrique
Krause, Gabriele Catyana
Scherer, Matheus
Romanato Santarém, Eliane
Rodrigues de Oliveira, Jarbas
Title: Therapeutic effect of Baccharis anomala DC. extracts on activated hepatic stellate cells
Language (ISO): en
Abstract: The therapeutic potential of Baccharis anomala DC. extracts was evaluated through its cytotoxic and antiproliferative effect and their phenotypic reversion property in activated hepatic stellate cells (HSCs). Baccharis anomala is distributed in Brazil (southeastern and south regions) and used for diuretic effect in folk medicine. Four fractions were obtained from the fractionation of the methanolic extract. Fractions III and IV decreased cell proliferation without increasing cell necrosis markers levels and induced cell cycle arrest in G1 phase. Fraction III induced phenotypic reversion through PPAR-γ activation pathway, while fraction IV did not alter PPAR-α/γ expression levels, suggesting that there is an independent PPAR-α/γ pathway involved. Hydroxybenzoic, chlorogenic and coumaric acids were identified. Fractions III and IV showed antiproliferative effect and ability to induce reversion of activated phenotype of HSCs.
Subject Headings: Hepatic fibrosis
HSCs
Baccharis
PPAR-γ
Phenolic compounds
URI: http://hdl.handle.net/2003/38068
http://dx.doi.org/10.17877/DE290R-20050
Issue Date: 2019-02-18
Appears in Collections:Original Articles

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