Full metadata record
DC FieldValueLanguage
dc.contributor.authorNasrolahi, Ava-
dc.contributor.authorMahmoudi, Javad-
dc.contributor.authorKarimipour, Mohammad-
dc.contributor.authorAkbarzadeh, Abolfazl-
dc.contributor.authorSadigh-Eteghad, Saeed-
dc.contributor.authorSalehi, Roya-
dc.contributor.authorFarajdokht, Fereshteh-
dc.contributor.authorFarhoudi, Mehdi-
dc.description.abstractThis study investigated the ability of intra-subventricular zone (SVZ) administration of cerebral dopamine neurotrophic factor (CDNF) on neural progenitor cells (NPCs) attraction from the SVZ toward the 6-hydroxydopamine (6-OHDA)-lesioned striatum and improvement of motor dysfunctions in Parkinsonian rats. Male Wistar rats were assigned to four groups of the sham model (Sham), 6-OHDA-lesioned (OH), 6-OHDA-lesioned plus CDNF vehicle (OH+Vehicle), and 6-OHDA-lesioned plus CDNF (OH+CDNF). The animal model of Parkinson's disease (PD) was induced by unilateral intra-striatal infusion of 6-OHDA. Rats in the treatment groups received an intra-SVZ injection of CDNF or the vehicle of CDNF two weeks after PD model induction and were then subjected to the beam and bar tests on days 7, 14, and 21 after CDNF injection. Bromodeoxyuridine (BrdU) was intraperitoneally injected to label newly generated cells. Migration and proliferation of NPCs were assessed by BrdU/doublecortin (DCX) double immunofluorescence method on days 7, 14, and 21 after CDNF infusion. 6-OHDA in the OH group induced catalepsy and increased elapsed time in the beam test compared to the Sham group. However, administration of CDNF improved the motor performance and increased the number of DCX expressing neuroblasts in the SVZ as compared to the OH and OH+Vehicle groups. CDNF also enhanced cell proliferation and increased the number of migrated BrdU- and DCX-positive cells toward the lesioned striatum in the OH+CDNF group. These results suggest that CDNF enhances the proliferation and migration of neural stem cells (NSCs) toward the lesioned striatum accompanied by improvement of PD-induced motor dysfunctions.en
dc.relation.ispartofseriesEXCLI Journal;Vol. 18 2019-
dc.subjectNeural stem/progenitor cellsen
dc.subjectNeuronal migrationen
dc.subjectParkinson's diseaseen
dc.titleEffect of cerebral dopamine neurotrophic factor on endogenous neural progenitor cell migration in a rat model of Parkinson's diseaseen
dcterms.accessRightsopen access-
Appears in Collections:Original Articles

Files in This Item:
File Description SizeFormat 
Mahmoudi_Farhoudi_05032019_proof.pdfDNB665.17 kBAdobe PDFView/Open
Mahmoudi_Farhoudi_05032019_supplementary_data.pdfDNB51.5 kBAdobe PDFView/Open

This item is protected by original copyright

Items in Eldorado are protected by copyright, with all rights reserved, unless otherwise indicated.