Authors: Dobrowolski, Adrian
Pieloth, Damian
Wiggers, Helmut
Thommes, Markus
Title: Electrostatic precipitation of submicron particles in a molten carrier
Language (ISO): en
Abstract: Recently, submicron particles have been discussed as a means to increase the bioavailability of poorly water-soluble drugs. Separation of these small particles is done with both fibre and membrane filters, as well as electrostatic precipitators. A major disadvantage of an electrostatic precipitator (ESP) is the agglomerate formation on the precipitation electrode. These agglomerates frequently show low bioavailability, due to the decreased specific surface area and poor wettability. In this work, a new melt electrostatic precipitator was developed and tested to convert submicron particles into a solid dispersion in order to increase the bioavailability of active pharmaceutical ingredients. The submicron particles were generated by spray drying and transferred to the ESP, where the collection electrode is covered with a melt, which served as matrix after solidification. The newly developed melt electrostatic precipitator was able to collect isolated naproxen particles in a molten carrier. A solid naproxen xylitol dispersion was prepared, which showed a reduction of the dissolution time by 82%, and a release of 80% of the total drug, compared to the physical mixture.
Subject Headings: Electrostatic precipitation
Spray drying
Submicron particles
Solubility
Bioavailability
Nanoparticles
Solid dispersion
Subject Headings (RSWK): Sprühtrocknung
Nanopartikel
URI: http://hdl.handle.net/2003/38143
http://dx.doi.org/10.17877/DE290R-20122
Issue Date: 2019-06-13
Appears in Collections:Lehrstuhl Feststoffverfahrenstechnik

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