Autor(en): Jagdhuber, Rudolf
Lang, Michel
Stenzl, Arnulf
Neuhaus, Jochen
Rahnenführer, Jörg
Titel: Cost-constrained feature selection in binary classification: adaptations for greedy forward selection and genetic algorithms
Sprache (ISO): en
Zusammenfassung: Background: With modern methods in biotechnology, the search for biomarkers has advanced to a challenging statistical task exploring high dimensional data sets. Feature selection is a widely researched preprocessing step to handle huge numbers of biomarker candidates and has special importance for the analysis of biomedical data. Such data sets often include many input features not related to the diagnostic or therapeutic target variable. A less researched, but also relevant aspect for medical applications are costs of different biomarker candidates. These costs are often financial costs, but can also refer to other aspects, for example the decision between a painful biopsy marker and a simple urine test. In this paper, we propose extensions to two feature selection methods to control the total amount of such costs: greedy forward selection and genetic algorithms. In comprehensive simulation studies of binary classification tasks, we compare the predictive performance, the run-time and the detection rate of relevant features for the new proposed methods and five baseline alternatives to handle budget constraints. Results: In simulations with a predefined budget constraint, our proposed methods outperform the baseline alternatives, with just minor differences between them. Only in the scenario without an actual budget constraint, our adapted greedy forward selection approach showed a clear drop in performance compared to the other methods. However, introducing a hyperparameter to adapt the benefit-cost trade-off in this method could overcome this weakness. Conclusions: In feature cost scenarios, where a total budget has to be met, common feature selection algorithms are often not suitable to identify well performing subsets for a modelling task. Adaptations of these algorithms such as the ones proposed in this paper can help to tackle this problem.
Schlagwörter: Feature cost
Genetic algorithm
Budget constraint
Cost limit
Feature selection
Schlagwörter (RSWK): Genetischer Algorithmus
Budgetbeschränkung
Kostenplanung
Merkmalsextraktion
URI: http://hdl.handle.net/2003/38554
http://dx.doi.org/10.17877/DE290R-20473
Erscheinungsdatum: 2020-01-28
Rechte (Link): https://creativecommons.org/licenses/by/4.0/
Enthalten in den Sammlungen:Statistische Methoden in der Genetik und Chemometrie

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
s12859-020-3361-9.pdf8.25 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource ist urheberrechtlich geschützt.



Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.