Full metadata record
DC FieldValueLanguage
dc.contributor.authorRazavi, Maryam-
dc.contributor.authorGhorbian, Saeid-
dc.date.accessioned2020-02-12T13:26:19Z-
dc.date.available2020-02-12T13:26:19Z-
dc.date.issued2019-06-17-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/38565-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20484-
dc.description.abstractLong non-coding RNA prostate cancer as sociated transcript-1 ncRNA (lncRNA-PCAT-1) plays an important role in the progression of prostate cancer. The present investigation was aimed to evaluate the potential roles of the lncRNA-PCAT-1 gene expression changes in esophageal squamous cell carcinoma (ESCC) between Iranian population. In the case-control investigation, we have anal yzed a total of 150 fresh tissue samples, compromising of 75 cancerous tissues and 75 adjacent normal tissues from patients with ESCC. We used quantitative Real-time polymerase chain reaction (qRT-PCR) to evaluate the lncRNA-PCAT-1 gene expression levels in ESCC patients and correlation between the lncRNA-PCAT-1 expression changes and clinical characteristics. Our findings showed that the lncRNA-PCAT-1 gene was up-regulated in cancerous tissues compared with the adjacent non-cancerous tissues (p=0.0016). In addition, the results revealed a significant correlation between up-regulating of lncRNA-PCAT-1 and hot liquid drinking (p =0.017). These findings offer the potential roles of lncRNA-PCAT-1 in the pathogenesis of ESCC and may consider as a candidate prognostic biomarker for ESCC in an Iranian population.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 18 2019-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectLncRNA-PCAT-1en
dc.subjectesophageal squamous cell carcinomaen
dc.subjectESCCen
dc.subjectlncRNAen
dc.subject.ddc610-
dc.titleUp-regulation of long non-coding RNA-PCAT-1 promotes invasion and metastasis in esophageal squamous cell carcinomaen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
eldorado.secondarypublicationtrue-
Appears in Collections:Original Articles

Files in This Item:
File Description SizeFormat 
Ghorbian_17062019_proof.pdfDNB239.37 kBAdobe PDFView/Open


This item is protected by original copyright



All resources in the repository are protected by copyright.