Authors: Rawat, Sarita
Gupta, Gaurav
Pathak, Sachchidanand
Singh, Santosh Kumar
Singh, Himmat
Mishra, Anurag
Gilhotra, Ritu
Aljabali, Alaa A. A.
Dureja, Harish
Tambuwala, Murtaza M.
Chellappan, Dinesh K.
Dua, Kamal
Title: Current biological and pharmacological updates on wogonin
Language (ISO): en
Abstract: Wogonin (5, 7-Dihydroxy-8-methoxyflavone) is a traditional naturally occurring flavonoid derived from the root extract of Chinese medicine, named Scutellaria baicalensis Georgi. Wogonin contains various biological properties which include allergic diseases, anti-cancertherapy and anti-inflammatory activities. Wogonin also shows the effects of removing toxins and cleansing heat. Wogonin glycosides are known as wogonosides. Oroxindin, a wogonin glucuronide isolated from Oroxylum indicum, is one of the example of wogonoside. It is also used in Japanese herbal supplement named Sho-Saiko-To, as an important active ingredient. One of the major active constituents of wogonin, Scutellaria baicalensis, shows potent anticancer activities both in vivo and in vitro studies. The anticancer therapeutic activity of wogonin has been shown by regulation of different cell signaling pathways , which includes protein kinase B pathway (serine-threonine kinase) and AMP-activated protein kinase pathways. Wogonin also shows positive therapeutic anticancer effects in breast cancer by inhibiting the 5‑LO/BLT2/ERK/IL‑8/MMP‑9 signaling cascade and established a major pharmacological anticancer activity.
Subject Headings: Wogonin
Anticancer
Antiinflammatory
Hepatoprotective
URI: http://hdl.handle.net/2003/39957
http://dx.doi.org/10.17877/DE290R-21847
Publishers Link: https://www.excli.de/index.php/excli/article/view/1967
Issue Date: 2020-05-13
Rights link: https://creativecommons.org/licenses/by/4.0/
Provenance: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Citation: Rawat, S., Gupta, G., Pathak, S., Singh, S. K., Singh, H., Mishra, A., Gilhotra, R., Aljabali, A. A. A., Dureja, H., Tambuwala, M. M., Chellappan, D. K., & Dua, K. (2020). Current biological and pharmacological updates on wogonin. EXCLI Journal, 19, 635-640. https://doi.org/10.17179/excli2020-1967
Appears in Collections:Letters to the Editor 2020

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