Authors: Sleziona, Dominik
Mattusch, Amelie
Schaldach, Gerhard
Ely, David R.
Sadowski, Gabriele
Thommes, Markus
Title: Determination of inherent dissolution performance of drug substances
Language (ISO): en
Abstract: The dissolution behavior of novel active pharmaceutical ingredients (API) is a crucial parameter in drug formulation since it frequently affects the drug release. Generally, a distinction is made between surface-reaction- and diffusion-controlled drug release. Therefore, dissolution studies such as the intrinsic dissolution test defined in the pharmacopeia have been performed for many years. In order to overcome the disadvantages of the common intrinsic dissolution test, a new experimental setup was developed within this study. Specifically, a flow channel was designed and tested for measuring the mass transfer from a flat, solid surface dissolving into a fluid flowing over the surface with well-defined flow conditions. A mathematical model was developed that distinguishes between surface-reaction- and diffusion-limited drug release based on experimental data. Three different drugs—benzocaine, theophylline and griseofulvin—were used to investigate the mass flux during dissolution due to surface reaction, diffusion and convection kinetics. This new technique shows potential to be a valuable tool for the identification of formulation strategies.
Subject Headings: Drug release
Flow channel
Intrinsic dissolution
Surface reaction
Two-film theory
Issue Date: 2021-01-22
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Appears in Collections:Lehrstuhl Feststoffverfahrenstechnik

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