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DC Element | Wert | Sprache |
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dc.contributor.author | Schmidt, Ann-Christin | - |
dc.contributor.author | Hiersemann, Martin | - |
dc.date.accessioned | 2022-03-04T13:49:13Z | - |
dc.date.available | 2022-03-04T13:49:13Z | - |
dc.date.issued | 2021-11-11 | - |
dc.identifier.uri | http://hdl.handle.net/2003/40764 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-22621 | - |
dc.description.abstract | (−)-Fusaequisin A is an irregularly assembled polyketide isolated from the ascomycete Fusarium equiseti. Fusaequisin A shares a carbon backbone with curvicollide C from the ascomycete Podospora curvicolla but its absolute configuration remained hitherto unsettled. Herein, we document the total synthesis of (−)-fusaequisin A and its 4-O-desmethyl derivative following a central-to-lateral building block strategy. Catalytic asymmetric Claisen rearrangement, Julia-Kocienski olefination and olefin cross-metathesis served as key C/C-connecting transformations. The constitution and absolute configuration of (−)-fusaequisin A was deduced and the original structural assignment was adjusted. | en |
dc.language.iso | en | de |
dc.relation.ispartofseries | Chemistry - a European journal;28(5) | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Asymmetric synthesis | en |
dc.subject | Natural products | en |
dc.subject | Polyketides | en |
dc.subject | Structural elucidation | en |
dc.subject | Total synthesis | en |
dc.subject.ddc | 540 | - |
dc.title | Total synthesis and structural assignment of (−)-fusaequisin A | en |
dc.type | Text | de |
dc.type.publicationtype | article | de |
dcterms.accessRights | open access | - |
eldorado.secondarypublication | true | de |
eldorado.secondarypublication.primaryidentifier | https://doi.org/10.1002/chem.202103558 | de |
eldorado.secondarypublication.primarycitation | A.-C. Schmidt, M. Hiersemann, Chem. Eur. J. 2022, 28, e202103558. | de |
Enthalten in den Sammlungen: | Organische Chemie |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Chemistry A European J - 2021 - Schmidt - Total Synthesis and Structural Assignment of ‐Fusaequisin A.pdf | DNB | 2.44 MB | Adobe PDF | Öffnen/Anzeigen |
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