Transition metal-free cycloisomerization of propargylic amides to oxazoles in hexafluoroisopropanol (HFIP)

Jankowski, Nicholas; Dietrich, Julian; Krause, Norbert

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DC Element	Wert	Sprache
dc.contributor.author	Jankowski, Nicholas	-
dc.contributor.author	Dietrich, Julian	-
dc.contributor.author	Krause, Norbert	-
dc.date.accessioned	2024-01-22T14:56:58Z	-
dc.date.available	2024-01-22T14:56:58Z	-
dc.date.issued	2022-08-08	-
dc.identifier.uri	http://hdl.handle.net/2003/42292	-
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-24128	-
dc.description.abstract	A transition metal-free method for the cycloisomerization of propargylic amides to oxazoles was developed. The reaction utilizes in situ generated hydrogen chloride in hexafluoroisopropanol (HFIP). With the aid of Design of Experiments optimization a wide range of substrates was transformed into the desired oxazoles. The method allows product formation without side reactions eliminating the need for extensive work-up and purification.	en
dc.language.iso	en	de
dc.relation.ispartofseries	Advanced synthesis & catalysis;364(19)	-
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	de
dc.subject	Brønsted acid catalysis	en
dc.subject	Cycloisomerization	en
dc.subject	Design of Experiments	en
dc.subject	Solvent effects	en
dc.subject	Transition metal-free synthesis	en
dc.subject.ddc	540	-
dc.title	Transition metal-free cycloisomerization of propargylic amides to oxazoles in hexafluoroisopropanol (HFIP)	en
dc.type	Text	de
dc.type.publicationtype	ResearchArticle	de
dcterms.accessRights	open access	-
eldorado.secondarypublication	true	de
eldorado.secondarypublication.primaryidentifier	https://doi.org/10.1002/adsc.202200559	de
eldorado.secondarypublication.primarycitation	N. Jankowski, J. Dietrich, N. Krause, Adv. Synth. Catal. 2022, 364, 3404.	de
Enthalten in den Sammlungen:	Organische Chemie

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Adv Synth Catal - 2022 - Jankowski - Transition Metal‐Free Cycloisomerization of Propargylic Amides to Oxazoles in.pdf	DNB	4.08 MB	Adobe PDF	Öffnen/Anzeigen

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