Authors: Biedermann, Stefanie
Dette, Holger
Zhu, Wei
Title: Optimal Designs for Dose-Response Models with Restricted Design Spaces
Language (ISO): en
Abstract: In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for estimating the underlying dose response curve. The underlying curve belongs to a diversified set of link functions suitable for the dose response studies and having a common canonical form. These include the fundamental binary response models – the logit and the probit as well as the skewed versions of these models. The results are illustrated through the re-design of a dose ranging trial conducted at the Merck Research Laboratories (Zeng and Zhu, 1997). This work is a generalization of the results of Dai and Zhu (2002) in terms of the design interval, the underlying dose response curve and the optimality criterion.
Subject Headings: binary response model
dose ranging
dose response
link function
general equivalence theorem
locally compound optimal design
information function
matrix mean
Issue Date: 2004
Provenance: Universitätsbibliothek Dortmund
Appears in Collections:Sonderforschungsbereich (SFB) 475

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