Higher risk of progressing breast cancer in Kurdish population associated to CDH1 -160 C/A polymorphism
| dc.contributor.author | Zarei, Farzaneh | |
| dc.contributor.author | Menbari, Mohammad Nazir | |
| dc.contributor.author | Ghaderi, Bayazid | |
| dc.contributor.author | Abdi, Mohammad | |
| dc.contributor.author | Vahabzadeh, Zakaria | |
| dc.date.accessioned | 2018-02-05T12:21:52Z | |
| dc.date.available | 2018-02-05T12:21:52Z | |
| dc.date.issued | 2017-11-06 | |
| dc.description.abstract | There is an increasing interest about studying possible effects of genetic polymorphisms and risk of cancer pro- gression. E-cadherin (CDH1) involves in many important cellular processes including cell-cell interactions, cell development and genetic changes of this molecule has been associated with greater tumor metastasis. The present study was aimed to evaluate the possible role of CDH1 -160 C/A polymorphism as a potential risk factor for breast cancer in Kurdish population. This case-control study consisted of 100 breast cancer patients and 200 healthy controls. Clinicopathological findings of all individuals were reported and immunohistochemistry staining was carried out on tissue samples. The CDH1 -160 C/A genotype was determined by polymerase chain reaction- re- striction fragment length polymorphism method (PCR-RFLP). CDH1 -160 C/A polymorphism was differently distributed between patient and control groups. The A allele of CDH1 -160 C/A polymorphism significantly in- creased in patients compared to controls. In addition we found that the A allele of this polymorphism might be a potential risk factor for progression of breast cancer in our studied population. Patients with A allele of CDH1 -160 C/A was in higher risk to progress invasive ductal carcinoma. The A allele was also correlated with high grade and stage IV and also with metastatic tumors in studied subjects. The CDH1 -160 C/A polymorphism is correlated with clinicopathologial findings of breast cancer patients. The A allele of CDH1 -160 C/A may be a risk factor for progression of breast cancer in Kurdish patients. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/36354 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18355 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 16 2017 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Breast cancer | en |
| dc.subject | CDH1 | en |
| dc.subject | Metastasis | en |
| dc.subject | Polymorphism | en |
| dc.subject | Prognosis | en |
| dc.subject.ddc | 610 | |
| dc.title | Higher risk of progressing breast cancer in Kurdish population associated to CDH1 -160 C/A polymorphism | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |