Higher risk of progressing breast cancer in Kurdish population associated to CDH1 -160 C/A polymorphism
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Date
2017-11-06
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Abstract
There is an increasing interest about studying possible effects of genetic polymorphisms and risk
of cancer pro- gression. E-cadherin (CDH1) involves in many important cellular processes including
cell-cell interactions, cell development and genetic changes of this molecule has been associated
with greater tumor metastasis. The present study was aimed to evaluate the possible role of CDH1
-160 C/A polymorphism as a potential risk factor for breast cancer in Kurdish population. This
case-control study consisted of 100 breast cancer patients and 200 healthy controls.
Clinicopathological findings of all individuals were reported and immunohistochemistry staining was
carried out on tissue samples. The CDH1 -160 C/A genotype was determined by polymerase chain
reaction- re- striction fragment length polymorphism method (PCR-RFLP). CDH1 -160 C/A polymorphism
was differently distributed between patient and control groups. The A allele of CDH1 -160 C/A
polymorphism significantly in- creased in patients compared to controls. In addition we found that
the A allele of this polymorphism might be a potential risk factor for progression of breast cancer
in our studied population. Patients with A allele of CDH1 -160 C/A was in higher risk to
progress invasive ductal carcinoma. The A allele was also correlated with high grade and stage IV
and also with metastatic tumors in studied subjects. The CDH1 -160 C/A polymorphism is correlated
with clinicopathologial findings of breast cancer patients. The A allele of CDH1 -160 C/A may be a
risk factor for progression of breast cancer in Kurdish patients.
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Keywords
Breast cancer, CDH1, Metastasis, Polymorphism, Prognosis