Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma

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dc.contributor.authorEftekhari, Parivash
dc.contributor.authorFoster, Paul S.
dc.contributor.authorHajizadeh, Sohrab
dc.contributor.authorHansbro, Nicole
dc.contributor.authorLi, Jing Jing
dc.contributor.authorMasjedi, Mohammad Reza
dc.contributor.authorRaoufy, Mohammad Reza
dc.contributor.authorYang, Ming
dc.date.accessioned2013-05-23T12:54:47Z
dc.date.available2013-05-23T12:54:47Z
dc.date.issued2013-05-23
dc.description.abstractOxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in an animal model of steroid resistant acute exacerbation of asthma. Systemically sensitized Balb/C mice were exposed to Ovalbumin aerosol on days 13, 14, 15 and 16, followed by intratracheal lipopolysaccharide (LPS) to induce acute exacerbation. NAC (intraperitoneal, 320 mg/kg 30 min before and 12 hours after each challenge) reduced hyperresponsiveness with/out dexamethasone. LPS application caused neutrophilia in bronchoalveolar lavage fluid (BALF) and eosinophil count was higher than respective control in BALF as well as neutrophils after dexamethasone treatment. NAC significantly decreased neutrophil and eosinophil count in BALF as well as inflammatory cytokines (IL-13 and IL-5).We concluded that addition of NAC to asthma therapy has beneficial preventive effects in an animal model of steroid resistant acute exacerbation of asthma.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/30348
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-10662
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectacute exacerbationen
dc.subjecteosinophilen
dc.subjectN-acetylcysteineen
dc.subjectneutrophilen
dc.subjectsteroid resistant asthmaen
dc.subject.ddc610
dc.titlePreventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthmaen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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