Electrostatic precipitation of submicron particles in a molten carrier

Dobrowolski, Adrian; Pieloth, Damian; Wiggers, Helmut; Thommes, Markus

Electrostatic precipitation of submicron particles in a molten carrier

dc.contributor.author	Dobrowolski, Adrian
dc.contributor.author	Pieloth, Damian
dc.contributor.author	Wiggers, Helmut
dc.contributor.author	Thommes, Markus
dc.date.accessioned	2019-07-12T13:40:38Z
dc.date.available	2019-07-12T13:40:38Z
dc.date.issued	2019-06-13
dc.description.abstract	Recently, submicron particles have been discussed as a means to increase the bioavailability of poorly water-soluble drugs. Separation of these small particles is done with both fibre and membrane filters, as well as electrostatic precipitators. A major disadvantage of an electrostatic precipitator (ESP) is the agglomerate formation on the precipitation electrode. These agglomerates frequently show low bioavailability, due to the decreased specific surface area and poor wettability. In this work, a new melt electrostatic precipitator was developed and tested to convert submicron particles into a solid dispersion in order to increase the bioavailability of active pharmaceutical ingredients. The submicron particles were generated by spray drying and transferred to the ESP, where the collection electrode is covered with a melt, which served as matrix after solidification. The newly developed melt electrostatic precipitator was able to collect isolated naproxen particles in a molten carrier. A solid naproxen xylitol dispersion was prepared, which showed a reduction of the dissolution time by 82%, and a release of 80% of the total drug, compared to the physical mixture.	de
dc.identifier.uri	http://hdl.handle.net/2003/38143
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-20122
dc.language.iso	en	de
dc.relation.ispartofseries	Pharmaceutics;
dc.subject	Electrostatic precipitation	de
dc.subject	Spray drying	de
dc.subject	Submicron particles	de
dc.subject	Solubility	de
dc.subject	Bioavailability	de
dc.subject	Nanoparticles	de
dc.subject	Solid dispersion	de
dc.subject.ddc	660
dc.subject.rswk	Sprühtrocknung	de
dc.subject.rswk	Nanopartikel	de
dc.title	Electrostatic precipitation of submicron particles in a molten carrier	de
dc.type	Text	de
dc.type.publicationtype	article	de
dcterms.accessRights	open access
eldorado.secondarypublication	true	de
eldorado.secondarypublication.primarycitation	Electrostatic Precipitation of Submicron Particles in a Molten Carrier (2019). Adrian Dobrowolski, Damian Pieloth, Helmut Wiggers and Markus Thommes. Pharmaceutics / Molecular Diversity Preservation International : Jg.: 11, Heft: 6 \| S. 276-282	de
eldorado.secondarypublication.primaryidentifier	https://doi.org/10.3390/pharmaceutics11060276	de

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