Pt(II) and Pd(II) complexes of isocytosine and guanine ligands

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dc.contributor.advisorLippert, B.
dc.contributor.authorGupta, Deepali
dc.contributor.refereeErxleben, A.
dc.date.accepted2005-09-16
dc.date.accessioned2005-10-05T09:05:10Z
dc.date.available2005-10-05T09:05:10Z
dc.date.issued2005-10-05T09:05:10Z
dc.description.abstractThe central idea behind the present project was the synthesis of the cationic di- and trinucleotide analogs with a positively charged Pt2+ backbone. The nucleobases can attach to the metal centers either through a) N1 (unsubstituted isocytosine base), via b) N9 (unsubstituted guanine base), c) N7 (9-EtGH) or d) N9 (7-MeGH) These cationic oligonucleotides are expected to be kinetically robust. Moreover, the nucleobases attached to the metal centers are forced in a more or less coplanar orientation and the hydrogen bonding properties are usually maintained. The cationic oligonucleotides can function as antisense and antigene reagents due to their ability to bind both DNA and RNA targets with high specificity and affinity. The ligands of choice for the present work were common and rare nucleobases such as isocytosine, guanine, 9-ethylguanine and 7-methylguanine. These ligands were studied with regard to the effects of metallation on hydrogen bonding properties and tautomerism. As it turned out, the planned fixation of a suitable metal entity to a particular site of a nucleobase or to a particular tautomer of a nucleobase in most cases is anything but trivial. Understanding factors which determine the reactivity of individual nucleobase tautomers toward metal species eventually proved to be essential.en
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dc.identifier.urihttp://hdl.handle.net/2003/21630
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-8276
dc.identifier.urnurn:nbn:de:hbz:290-2003/21630-6
dc.language.isoen
dc.subjectTautomerismen
dc.subjectHydrogen bondingen
dc.subjectLinkage isomerismen
dc.subjectIsocytosineen
dc.subjectCationic oligonucleotideen
dc.subjectGuanineen
dc.subject9-ethylguanineen
dc.subject7-methylguanineen
dc.subjectRaman spectroscopyen
dc.subjectNMR spectroscopyen
dc.subjectDFT calculationsen
dc.subject.ddc540
dc.titlePt(II) and Pd(II) complexes of isocytosine and guanine ligandsen
dc.title.alternativetautomerism, linkage isomerism and hydrogen bondingen
dc.typeTexten
dc.type.publicationtypedoctoralThesisen
dcterms.accessRightsopen access

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