Improved in vitro test procedure for full assessment of the cytocompatibility of degradable magnesium based on ISO 10993-5/-12

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dc.contributor.authorKlein, Martin
dc.contributor.authorWegner, Nils
dc.contributor.authorWalther, Frank
dc.contributor.authorStangier, Dominic
dc.contributor.authorJung, Ole
dc.contributor.authorSmeets, Ralf
dc.contributor.authorHartjen, Philip
dc.contributor.authorSchnettler, Reinhard
dc.contributor.authorFeyerabend, Frank
dc.contributor.authorHenningsen, Anders
dc.contributor.authorRendenbach, Carsten
dc.contributor.authorHeiland, Max
dc.contributor.authorBarbeck, Mike
dc.contributor.authorKopp, Alexander
dc.date.accessioned2019-11-11T15:13:54Z
dc.date.available2019-11-11T15:13:54Z
dc.date.issued2019-01-10
dc.description.abstractMagnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and the related (micro-) milieu conditions pretend to strictly follow in vitro standards based on ISO 10993-5/-12. Thus, special adaptions for the testing of Mg materials are necessary, which have been described in a previous study from our group. Based on these adaptions, further developments of a test procedure allowing rapid and effective in vitro cytocompatibility analyses of Mg-based materials based on ISO 10993-5/-12 are necessary. The following study introduces a new two-step test scheme for rapid and effective testing of Mg. Specimens with different surface characteristics were produced by means of plasma electrolytic oxidation (PEO) using silicate-based and phosphate-based electrolytes. The test samples were evaluated for corrosion behavior, cytocompatibility and their mechanical and osteogenic properties. Thereby, two PEO ceramics could be identified for further in vivo evaluations.en
dc.identifier.urihttp://hdl.handle.net/2003/38332
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20302
dc.language.isoende
dc.relation.ispartofseriesInternational journal of molecular sciences;Jg. 20, Heft 2. S. 255-1-255-20
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMagnesiumde
dc.subjectISO10993-5/-12en
dc.subjectPEOen
dc.subjectDegradationen
dc.subjectBiocompatibilityen
dc.subjectImplanten
dc.subject.ddc660
dc.titleImproved in vitro test procedure for full assessment of the cytocompatibility of degradable magnesium based on ISO 10993-5/-12en
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationInternational journal of molecular sciences : Jg.: 20, Heft: 2. S. 255-1-255-20de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.3390/ijms20020255de

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