A novel medium size lactam ring analoges as antibacterial agents

dc.contributor.authorPutcha A. N. V., Harita
dc.contributor.authorPutcha, Seshi Kumar
dc.contributor.authorGuduru, Shiva Krishna Reddy
dc.contributor.authorRavula, Parameshwar
dc.contributor.authorSharath Chandra, J N Narendra
dc.date.accessioned2017-11-27T14:33:34Z
dc.date.available2017-11-27T14:33:34Z
dc.date.issued2017-08-14
dc.description.abstractA novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4]diazonine-2,5-dione (6a-f) analogues were synthesized from (E)-3-(2-nitrophenyl)acrylicacid (2) reacting with various amino acid esters using Di-isopropyl Carbodiimide as a coupling agent. The final cyclization is carried out by using reagent 1-Ethyl-3(3- dimethylaminopropyl) Carbodiimide Hydrochloride. The synthesized compounds have been supported by Mass, 1H-NMR and 13C-NMR. Further antibacterial studies were conducted, where some molecules are noticed with potent activity, especially molecule 6d shown highest activity which was also supported by molecular docking studies. All final molecules were docked with enzyme peptide deformylase to determine the probable binding conformation.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36211
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18225
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectmedium size ringen
dc.subjectsynthesisen
dc.subjectcoupling reactionen
dc.subjectlactamen
dc.subjectbacillus subtilisen
dc.subjectanti-bacterialen
dc.subjectdockingen
dc.subject.ddc610
dc.titleA novel medium size lactam ring analoges as antibacterial agentsen
dc.title.alternativesynthesis, biological evaluation and molecular docking studiesen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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