A novel medium size lactam ring analoges as antibacterial agents
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Date
2017-08-14
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Abstract
A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4]diazonine-2,5-dione (6a-f) analogues
were synthesized from (E)-3-(2-nitrophenyl)acrylicacid (2) reacting with various amino acid esters using
Di-isopropyl Carbodiimide as a coupling agent. The final cyclization is carried out by using reagent 1-Ethyl-3(3-
dimethylaminopropyl) Carbodiimide Hydrochloride. The synthesized compounds have been supported by Mass,
1H-NMR and 13C-NMR. Further antibacterial studies were conducted, where some molecules are noticed with
potent activity, especially molecule 6d shown highest activity which was also supported by molecular docking
studies. All final molecules were docked with enzyme peptide deformylase to determine the probable binding
conformation.
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Keywords
medium size ring, synthesis, coupling reaction, lactam, bacillus subtilis, anti-bacterial, docking