Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer

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dc.contributor.authorZimmer, Philipp
dc.contributor.authorEsser, Tobias
dc.contributor.authorLueftner, Diana
dc.contributor.authorSchuetz, Florian
dc.contributor.authorBaumann, Freerk T.
dc.contributor.authorRody, Achim
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorHartkopf, Andreas D.
dc.contributor.authorDecker, Thomas
dc.contributor.authorUleer, Christoph
dc.contributor.authorStoetzer, Oliver J.
dc.contributor.authorFoerster, Frank
dc.contributor.authorSchmidt, Marcus
dc.contributor.authorMundhenke, Christoph
dc.contributor.authorSteindorf, Karen
dc.contributor.authorTesch, Hans
dc.contributor.authorJackisch, Christian
dc.contributor.authorFischer, Thomas
dc.contributor.authorHanson, Sven
dc.contributor.authorKreuzeder, Julia
dc.contributor.authorGuderian, Gernot
dc.contributor.authorFasching, Peter A.
dc.contributor.authorBloch, Wilhelm
dc.date.accessioned2025-06-17T12:49:04Z
dc.date.available2025-06-17T12:49:04Z
dc.date.issued2024-10-08
dc.description.abstractBackground: Increased levels of physical activity are associated with a reduction of breast cancer mortality, especially in postmenopausal women with positive hormone receptor status. So far, previous observational case–control and cohort studies have focused on associations between overall leisure time physical activity and survival of women with breast cancer in general. Methods: In this multicenter prospective cohort study, conducted in Germany between 30th August 2012 to 29th December 2017, we investigated general physical activity in a homogenous sample of n = 1440 postmenopausal women with advanced (inoperable locally advanced or metastatic), hormone receptor-positive breast cancer receiving the same therapy (everolimus and exemestane). Self-reported physical activity was assessed using the Godin Leisure Time Exercise Questionnaire (GLTEQ) before and every 3 months during treatment. Participants were then classified into “active” and “insufficiently active” to screen their activity behavior the week prior to medical treatment. In addition, changes in physical activity patterns were assessed. Adjusted Cox regression analyses were performed for the activity categories to determine hazard ratios (HR). Besides progression-free survival (PFS), adverse events (AEs), QoL, and fatigue were assessed every 3 months until study termination. Results: Compared to “insufficiently active” patients, “active” individuals indicated a significantly longer PFS (HR: 0.84 [0.74; 0.984], p = .0295). No significant differences were observed for changes of physical activity behavior. Patients who reported to be “active” at baseline revealed significantly fewer AEs compared to “insufficiently” active patients. In detail, both severe and non-severe AEs occurred less frequently in the “active” patients group. In line with that, QoL and fatigue were better in physical “active” patients compared to their insufficient active counterparts at the last post-baseline assessment. Participants who remained or become active indicated less AEs, a higher QoL, and reduced fatigue levels. Conclusions: Physical activity behavior prior to medical treatment might have prognostic value in patients with advanced breast cancer in terms of extending the PFS. Moreover, physical activity before and during treatment may reduce treatment-related side effects and improve patients’ QoL and fatigue. Trial registration: EUPAS9462. Registered 30th October 2012 “retrospectively registered.”en
dc.identifier.urihttp://hdl.handle.net/2003/43754
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-25528
dc.language.isoen
dc.relation.ispartofseriesBMC medicine; 22
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPhysical activityen
dc.subjectExerciseen
dc.subjectBreast canceren
dc.subjectAdverse eventsen
dc.subjectSurvivalen
dc.subjectFatigueen
dc.subjectQuality of lifeen
dc.subject.ddc796
dc.subject.rswkSport
dc.subject.rswkKörperliche Aktivität
dc.subject.rswkBrustkrebs
dc.subject.rswkLetalität
dc.subject.rswkLebensqualität
dc.subject.rswkErschöpfung
dc.titlePhysical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast canceren
dc.typeText
dc.type.publicationtypeResearchArticle
dcterms.accessRightsopen access
eldorado.secondarypublicationtrue
eldorado.secondarypublication.primarycitationZimmer, P., Esser, T., Lueftner, D. et al. Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer. BMC Med 22, 442 (2024). https://doi.org/10.1186/s12916-024-03671-x
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1186/s12916-024-03671-x

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