Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking

Simple item page
dc.contributor.authorRomanovska, Alina
dc.contributor.authorSchmidt, Martin
dc.contributor.authorBrandt, Volker
dc.contributor.authorTophoven, Jonas
dc.contributor.authorTiller, Joerg C.
dc.date.accessioned2025-12-17T07:39:57Z
dc.date.available2025-12-17T07:39:57Z
dc.date.issued2024-02-21
dc.description.abstractDrugs that form self-assembled supramolecular structures to be most-active is a promising way of creating new highly specific and active pharmaceuticals. Controlling the activity of bioactive supramolecular structures such as drug-loaded micelles is possible by both core/shell and inter-assembly cross-linking. However, if the flexibility of the assembly is mandatory for the activity cross-linking is not feasible. Thus, such structures cannot be manipulated in their activity. The present study demonstrates a novel concept to control the activity of not drug-releasing, non-cross-linked bioactive superstructures. This is achieved by formation of nanostructured nanoparticles derived by non-covalent inter-assembly cross-linking of the superstructures. This is shown on the example of amphiphilic diblock-copolymers conjugated with the antibiotic ciprofloxacin (CIP). These polymer-antibiotic conjugates form worm micelles, which greatly activate the conjugated antibiotic without releasing it. Non-covalent inter-assembly cross-linking of these CIP-worm-micelles with amphiphilic triblock copolymers terminated with lipase-cleavable esters leads to nanostructured nanoparticles that resemble cross-linked worm micelles and show an up to 135-fold lower activity than the free worm micelles. The activity of the worm-micelles can be fully recovered by cleaving the end groups of the polymeric cross-linker with lipase.en
dc.identifier.urihttp://hdl.handle.net/2003/44560
dc.language.isoen
dc.relation.ispartofseriesJournal of controlled release; 368
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPolymer antibtiotic conjugateen
dc.subjectCiprofloxacinen
dc.subjectCross-linked micellesen
dc.subjectLipase-induced releaseen
dc.subjectPoly(2-oxazoline)en
dc.subject.ddc660
dc.titleControlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linkingen
dc.typeText
dc.type.publicationtypeArticle
dcterms.accessRightsopen access
eldorado.dnb.deposittrue
eldorado.doi.registerfalse
eldorado.secondarypublicationtrue
eldorado.secondarypublication.primarycitationAlina Romanovska, Martin Schmidt, Volker Brandt, Jonas Tophoven, Joerg C. Tiller, Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking, Journal of Controlled Release, Volume 368, 2024, Pages 15-23, https://doi.org/10.1016/j.jconrel.2024.02.013
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1016/j.jconrel.2024.02.013

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0168365924001007-main.pdf
Size:
5.57 MB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.82 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Lehrstuhl Biomaterialien und Polymerwissenschaften