β-Cyclodextrin-basierte N-Heterocyclische Carben- Gold(I)-Komplexe

Sak, Hülya

β-Cyclodextrin-basierte N-Heterocyclische Carben- Gold(I)-Komplexe

dc.contributor.advisor	Krause, Norbert
dc.contributor.author	Sak, Hülya
dc.contributor.referee	Jurkschat, Klaus
dc.date.accepted	2018-08-24
dc.date.accessioned	2018-09-06T06:02:09Z
dc.date.available	2018-09-06T06:02:09Z
dc.date.issued	2018
dc.description.abstract	The concept of sustainability is a broadly investigated topic in the modern organic chemistry which gains more and more importance and affects the development of novel strategies. According to green chemistry, an important issue of catalytic reactions is the recyclability of the catalyst and a simple separation of products. As a method for catalyst recycling, the use of water as solvent is utilized and the recovery of the hydrophilic catalyst can be achieved by extraction of the hydrophobic products, allowing the reuse of catalyst in the aqueous media. To enable water-solubility of a gold catalyst, the research of this thesis is focused on the combination of NHC ligands with a β-cyclodextrin moiety, and on the use of the novel water soluble β-cyclodextrin-NHC-gold complexes in gold-catalyzed transformations in water. Besides modular construction of β-cyclodextrin-NHC-gold complexes, click chemistry as an alternative approach was demonstrated. The binding of the two molecular building blocks was carried out by copper- and ruthenium-catalyzed azide-alkyne cycloaddition. The diversity of the gentle conditions were used to synthesize further β-cyclodextrin-NHC-gold complexes via 1,3-dipolar cycloaddition. In addition, initial results on the catalytic activity and reusability of the catalysts in aqueous media by investigation of gold-catalyzed cycloisomerizations were presented. Furthermore bifunctional β-Cyclodextrin-tagged compounds bearing a SiFA moiety (SiFA = silicon-fluoride-acceptor) were synthesized, which can be applied in positron emission tomography. Moreover, kinetic studies on the rate determining step of the gold-catalyzed cycloisomerization of α-functionalized allenes were performed with various phosphine- and phosphit catalysts in organic solvents.	de
dc.identifier.uri	http://hdl.handle.net/2003/37123
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-19119
dc.language.iso	de	de
dc.subject	β-Cyclodextrin	de
dc.subject	NHC	de
dc.subject	Gold	de
dc.subject	Katalyse	de
dc.subject	Recycling	de
dc.subject	Wasser	de
dc.subject	SiFA-Verbindungen	de
dc.subject.ddc	540
dc.subject.rswk	Katalyse	de
dc.subject.rswk	Gold	de
dc.title	β-Cyclodextrin-basierte N-Heterocyclische Carben- Gold(I)-Komplexe	de
dc.title.alternative	Synthesewege, Beiträge zur nachhaltigen Chemie und weitere Studien	de
dc.type	Text	de
dc.type.publicationtype	doctoralThesis	de
dcterms.accessRights	open access
eldorado.secondarypublication	false	de

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Organische Chemie