Development of contractive synthesis of cyclobutanes from pyrrolidines

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dc.contributor.advisorWaldmann, Herbert
dc.contributor.authorHui, Chun-Ngai
dc.contributor.refereeAntonchick, Andrey P.
dc.date.accepted2021-12-20
dc.date.accessioned2022-02-02T06:52:45Z
dc.date.available2022-02-02T06:52:45Z
dc.date.issued2021
dc.description.abstractCarbocycles are omnipresence in chemical pharmaceuticals, biologically active natural products and organic functional materials. Construction of structurally intriguing, highly functionalized small carbocycles with congested stereocenters remain to be an intricate task in organic chemistry. Consistent endeavor such as innovation of chemical methodology and development of synthetic tactics has been made to improve the synthetic efficiency to these complex structures. In particular, the synthesis of carbocycle through ring contraction, which complies with the concept of synthetic efficiency in modern organic chemistry, has been widely applied in organic synthesis of complex architectures. In this thesis, the unprecedented, stereospecific and contractive synthesis of multi-substituted cyclobutanes from corresponding pyrrolidines is discussed. The reaction mechanism is investigated and the reaction was applied to the synthesis of cytotoxic natural product piperarborenine B.en
dc.identifier.urihttp://hdl.handle.net/2003/40708
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-22566
dc.language.isoende
dc.subjectCyclobutanesen
dc.subjectIodonitrenes' contractive synthesisen
dc.subjectNatural product synthesisen
dc.subject.ddc570
dc.subject.ddc540
dc.subject.rswkNaturstoffchemiede
dc.subject.rswkCyclobutanderivatede
dc.titleDevelopment of contractive synthesis of cyclobutanes from pyrrolidinesen
dc.typeTextde
dc.type.publicationtypedoctoralThesisde
dcterms.accessRightsopen access
eldorado.secondarypublicationfalsede

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