A haplotype of the phosphodiesterase 4D (PDE4D) gene is associated with myocardial infarction and with cardiometabolic parameters

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dc.contributor.authorRodríguez-Pérez, José Manuel
dc.contributor.authorPosadas-Sánchez, Rosalinda
dc.contributor.authorBlachman-Braun, Ruben
dc.contributor.authorVargas-Alarcón, Gilberto
dc.contributor.authorPosadas-Romero, Carlos
dc.contributor.authorGarcía-Flores, Esbeidy
dc.contributor.authorLópez-Bautista, Fabiola
dc.contributor.authorTovilla-Zárate, Carlos Alfonso
dc.contributor.authorGonzález-Castro, Thelma Beatriz
dc.contributor.authorBorgonio-Cuadra, Verónica Marusa
dc.contributor.authorPérez-Hernández, Nonanzit
dc.date.accessioned2019-04-05T07:55:58Z
dc.date.available2019-04-05T07:55:58Z
dc.date.issued2018-12-19
dc.description.abstractThe phosphodiesterase family is involved in a wide spectrum of diseases, including ischemic stroke. However, few studies have analyzed the relationship between phosphodiesterase 4D (PDE4D) and myocardial infarction (MI). Therefore, the aim of this research was to evaluate the association of the PDE4D gene polymorphisms with MI, and with cardiometabolic parameters in the Mexican population. Six polymorphisms (rs2910829, rs1423246, rs966221, rs4502776, rs13172481, and rs6869495) were genotyped in 1023 MI patients and 1105 healthy controls. A similar distribution of the six polymorphisms was observed in both studied groups. However, after evaluating the linkage disequilibrium, we detected a risk haplotype for MI (AGAGAA; OR = 1.148; P = 0.025). In addition, the polymorphisms were associated with the presence of some clinical and metabolic parameters (central obesity, hypertriglyceridemia, Aspartate transaminase >p75, Lipoprotein (a) >30 mg/dL, TAT >p75, fatty liver, and vitamin D <30 ng/dL) in healthy controls. The results suggest that in the Mexican population, a PDE4D haplotype is associated with increased risk of developing MI, and that PDE4D polymorphisms are independently associated with the presence of cardiometabolic parameters.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37984
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19968
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPhosphodiesteraseen
dc.subjectMyocardial infarctionen
dc.subjectPolymorphismsen
dc.subjectMexican populationen
dc.subject.ddc610
dc.titleA haplotype of the phosphodiesterase 4D (PDE4D) gene is associated with myocardial infarction and with cardiometabolic parametersen
dc.title.alternativethe GEA studyen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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