A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
| dc.contributor.author | Pingaew, Ratchanok | |
| dc.contributor.author | Prachayasittikul, Supaluk | |
| dc.contributor.author | Prachayasittikul, Virapong | |
| dc.contributor.author | Ruchirawat, Somsak | |
| dc.contributor.author | Worachartcheewan, Apilak | |
| dc.date.accessioned | 2010-11-17T09:07:46Z | |
| dc.date.available | 2010-11-17T09:07:46Z | |
| dc.date.issued | 2010-11-17 | |
| dc.description.abstract | Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tetrahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively. | en |
| dc.identifier.uri | http://hdl.handle.net/2003/27472 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-15807 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 9, 2010 | en |
| dc.subject | 4-phenylpyridine l-oxide | en |
| dc.subject | antimicrobial activity | en |
| dc.subject | sulfonium ion | en |
| dc.subject | sulfoxide | en |
| dc.subject | tetrahydropyridine | en |
| dc.subject.ddc | 610 | |
| dc.title | A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |