A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
Loading...
Date
2010-11-17
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tetrahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported.
Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV.
The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.
Description
Table of contents
Keywords
4-phenylpyridine l-oxide, antimicrobial activity, sulfonium ion, sulfoxide, tetrahydropyridine