In vitro transfection of anti-tumor miR-101 induces BIM, a pro-apoptotic protein, expression in acute myeloid leukemia (AML)
Loading...
Date
2017-11-27
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Acute myeloid leukemia (AML) frequently relapses after initial treatment, though it is possible
that drug resistance occurs. Hence, it seems necessary to develop novel therapies such as gene
therapy specifically via miRNA trans- fection. MicroRNA-101 has been considered as a tumor
suppressor in different types of cancer. It is demonstrated that exogenous miR-101 transfection is
associated with decreased viability in AML in this paper. Besides, the increase of pro-apoptotic
protein BIM expression in both mRNA and protein level has been illustrated. The recent findings
provide an insight into the novel function of miR-101 in AML by activating BIM as an important
mediator in intrinsic apoptosis pathways. Generally, miR-101 has been considered as a therapeutic
target in our data and might have a valuable role in AML.
Description
Table of contents
Keywords
AML, miR-101, BIM, Apoptosis