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In vitro transfection of anti-tumor miR-101 induces BIM, a pro-apoptotic protein, expression in acute myeloid leukemia (AML)

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dc.contributor.authorNikoonahad Lotfabadi, Narges
dc.contributor.authorMohseni Kouchesfahani, Homa
dc.contributor.authorSheikhha, Mohammad Hasan
dc.contributor.authorKalantar, Seyed Mehdi
dc.date.accessioned2018-02-05T13:14:56Z
dc.date.available2018-02-05T13:14:56Z
dc.date.issued2017-11-27
dc.description.abstractAcute myeloid leukemia (AML) frequently relapses after initial treatment, though it is possible that drug resistance occurs. Hence, it seems necessary to develop novel therapies such as gene therapy specifically via miRNA trans- fection. MicroRNA-101 has been considered as a tumor suppressor in different types of cancer. It is demonstrated that exogenous miR-101 transfection is associated with decreased viability in AML in this paper. Besides, the increase of pro-apoptotic protein BIM expression in both mRNA and protein level has been illustrated. The recent findings provide an insight into the novel function of miR-101 in AML by activating BIM as an important mediator in intrinsic apoptosis pathways. Generally, miR-101 has been considered as a therapeutic target in our data and might have a valuable role in AML.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36358
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18359
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAMLen
dc.subjectmiR-101en
dc.subjectBIMen
dc.subjectApoptosisen
dc.subject.ddc610
dc.titleIn vitro transfection of anti-tumor miR-101 induces BIM, a pro-apoptotic protein, expression in acute myeloid leukemia (AML)en
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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