Protein arginine methyltransferase 5 promotes bladder cancer growth through inhibiting NF-kB dependent apoptosis
Loading...
Date
2018-11-20
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Protein arginine methyltransferase 5 (PRMT5) has emerged as a key regulator of tumorigenesis. However, how
PRMT5 functions in bladder cancer, the most common malignancy of the urological system, is unknown. We
described here that PRMT5 is highly expressed in bladder cancer cell lines and primary human bladder cancer
tissues. PRMT5 enhances the proliferation and colony formation of bladder cancer cells. PRMT5 knockdown
induces bladder cancer cell apoptosis. Mechanistically, PRMT5 enhances NF-kB activation by targeting crucial
anti-apoptotic genes such as BCLXL and c-IAP1, thereby inhibiting tumor cell apoptosis and sustaining proliferation.
Importantly, PRMT5 inhibitor opposed tumor growth and BCLXL and c-IAP1 transcription in the bladder
cancer xenograft model. Collectively, the current suggests the crucial role of PRMT5 as a promising therapeutic
target in bladder cancers.
Description
Table of contents
Keywords
PRMT5, Bladder cancer, NF-kB, Apoptosis