Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower
| dc.contributor.author | Kim, Min-Jin | |
| dc.contributor.author | Yang, Kyong-Wol | |
| dc.contributor.author | Kim, Sang Suk | |
| dc.contributor.author | Park, Suk Man | |
| dc.contributor.author | Park, Kyung Jin | |
| dc.contributor.author | Kim, Kwang Sik | |
| dc.contributor.author | Choi, Young Hun | |
| dc.contributor.author | Cho, Kwang Keun | |
| dc.contributor.author | Lee, Nam Ho | |
| dc.contributor.author | Hyun, Chang-Gu | |
| dc.date.accessioned | 2014-03-12T13:52:03Z | |
| dc.date.available | 2014-03-12T13:52:03Z | |
| dc.date.issued | 2013-11-07 | |
| dc.description.abstract | A number of essential oils derived from plants are claimed to have several medicinal functions, including anti-cancer and anti-inflammation effects. However, the chemical composition and biological activities of flower-derived components have not been sufficiently characterized. Therefore, we investigated the composition of essential oils from Hallabong flower [(Citrus unshiu Marcov × Citrus sinensis Osbeck) × Citrus reticulata Blanco] and their anti-inflammatory effects. Hydro-dist illed essential oils (HEOs) were analyzed using gas chromatography–mass spectrometry (GC–MS). In total, 21 components were identified, representing more than 98 % of the oils, with sabinene (34.75 %), linalool (14.77 %), β-ocimene (11.07 %), 4-terpineol (9.63 %), L-limonene (5.88 %), and γ-terpinene (4.67 %) as the main components. In the present study, we also investigated the anti-inflammatory effects of HEOs on lipopolysaccharide (LPS)-stimulated RAW 26 4.7 macrophage cells. HEOs were found to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production and to suppress the LPS- induced expression of cyclooxygenase-2 (COX-2) protein. In addition, HEOs downregulated the production of the inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1 β(IC50 values are 0.05 %, 0.02 %, and 0.01 %, respectively). On the basis of these results, we suggest that HEOs can be consid ered potential anti-inflammatory candidates for therapeutic use in humans. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/32970 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7370 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 12, 2013 | en |
| dc.subject | chemical composition | en |
| dc.subject | citrus flower | en |
| dc.subject | essential oil | en |
| dc.subject | inflammation | en |
| dc.subject | Hallabong | en |
| dc.subject.ddc | 610 | |
| dc.title | Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |