Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower
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Date
2013-11-07
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Abstract
A number of essential oils derived from plants are claimed to have several medicinal functions, including anti-cancer and anti-inflammation effects. However, the chemical composition and biological activities of flower-derived components have
not been sufficiently characterized. Therefore, we investigated the composition of essential oils from Hallabong flower
[(Citrus unshiu Marcov × Citrus sinensis
Osbeck) × Citrus reticulata Blanco] and their anti-inflammatory effects. Hydro-dist
illed essential oils (HEOs) were analyzed using gas chromatography–mass spectrometry (GC–MS). In total, 21 components were identified, representing more than 98 % of the oils, with sabinene (34.75 %), linalool (14.77 %), β-ocimene (11.07 %), 4-terpineol (9.63 %), L-limonene (5.88 %), and γ-terpinene (4.67 %) as the main components. In the present study, we also investigated the anti-inflammatory effects of HEOs on lipopolysaccharide (LPS)-stimulated RAW 26
4.7 macrophage cells. HEOs were found to
inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production and to suppress the LPS-
induced expression of cyclooxygenase-2 (COX-2) protein. In addition, HEOs downregulated the production of the inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1
β(IC50 values are 0.05 %, 0.02 %, and 0.01 %, respectively). On the basis of these
results, we suggest that HEOs can be consid
ered potential anti-inflammatory candidates for therapeutic use in humans.
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Keywords
chemical composition, citrus flower, essential oil, inflammation, Hallabong