lncRNA involvement in hepatocellular carcinoma metastasis and prognosis

dc.contributor.authorAbbastabar, Maryam
dc.contributor.authorSarfi, Mohammad
dc.contributor.authorGolestani, Abolfazl
dc.contributor.authorKhalili, Ehsan
dc.date.accessioned2019-04-05T10:58:14Z
dc.date.available2019-04-05T10:58:14Z
dc.date.issued2018-09-04
dc.description.abstractEukaryotic lncRNAs are RNA molecules defined to be greater than 200 bp in length that are not translated to a protein and operate through several mechanisms, including participating in chromatin remodeling and methylation, influencing the integrity and stability of proteins and complexes, or acting as a sponge for miRNA inhibition. A number of recent studies have concentrated on the relationship between long non-coding RNAs (lncRNAs) and cancer. Hepatocellular carcinoma (HCC) is the most prevalent histological type of liver tumors, accounting for about 80 % of the cases worldwide. Lack of proper molecular markers for diagnosis of HCC and treatment evaluation is a significant problem. Dysregulated expression of HCC-related lncRNAs such as MEG-3, MALAT1, HULC, HOTAIR, and H19 have been identified and closely related with tumorigenesis, metastasis, prognosis and diagnosis. In this review, we summarized recent highlighted functions and molecular mechanisms of the most extensively studied lncRNAs in the pathophysiology of hepatocellular carcinoma and their potential for serving as probable therapeutic targets.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37987
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19970
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHepatocellular carcinoma (HCC)en
dc.subjectlong non-coding RNA (lncRNAs)en
dc.subjectMetastasisen
dc.subjectPrognosisen
dc.subjectLiveren
dc.subject.ddc610
dc.titlelncRNA involvement in hepatocellular carcinoma metastasis and prognosisen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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