lncRNA involvement in hepatocellular carcinoma metastasis and prognosis
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Date
2018-09-04
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Abstract
Eukaryotic lncRNAs are RNA molecules defined to be greater than 200 bp in length that are
not translated to a protein and operate through several mechanisms, including participating in
chromatin remodeling and methylation, influencing the integrity and stability of proteins and
complexes, or acting as a sponge for miRNA inhibition. A number of recent studies have concentrated
on the relationship between long non-coding RNAs (lncRNAs) and cancer. Hepatocellular
carcinoma (HCC) is the most prevalent histological type of liver tumors, accounting
for about 80 % of the cases worldwide. Lack of proper molecular markers for diagnosis of HCC
and treatment evaluation is a significant problem. Dysregulated expression of HCC-related
lncRNAs such as MEG-3, MALAT1, HULC, HOTAIR, and H19 have been identified and
closely related with tumorigenesis, metastasis, prognosis and diagnosis. In this review, we summarized
recent highlighted functions and molecular mechanisms of the most extensively studied
lncRNAs in the pathophysiology of hepatocellular carcinoma and their potential for serving
as probable therapeutic targets.
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Keywords
Hepatocellular carcinoma (HCC), long non-coding RNA (lncRNAs), Metastasis, Prognosis, Liver